HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-[3-(3-Trifluoromethylphenyl)-5-Isoxazolyl]Benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-[3-(3-trifluoromethylphenyl)-5-isoxazolyl]benzoate | HCID 13018699 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[3-(3-Trifluoromethylphenyl)-5-Isoxazolyl]Benzoic Acid | HCID 12789638 | 65% |
Reaction Steps
A solution of 6.20 g of methyl 2-[3-(3-trifluoromethylphenyl)-5-isoxazolyl]benzoate, 75 ml. of acetic acid, and 50 ml. of concentrated HCl was held at reflux for 4 hours, cooled, and poured into 450 ml. of cold water. The resultant solid was recrystallized from CH3CN to give 3.87 g of solid, mp 176°-177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04229204 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-baaa0a85bfbe4811a7661aa31c25f90b |
| Source note | uspto-grants-1980_10 |