反应详情

A solution of 6.20 g of methyl 2-[3-(3-trifluoromethylphenyl)-5-isoxazolyl]benzoate, 75 ml. of acetic acid, and 50 ml. of concentrated HCl was held at reflux for 4 hours, cooled, and poured into 450 ml. of cold water. The resultant solid was recrystallized from CH3CN to give 3.87 g of solid, mp 176°-177° C.

1. temperatureat reflux for 4 hours
2. temperaturecooled
3. additionpoured into 450 ml
4. customThe resultant solid was recrystallized from CH3CN