HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloro-4-nitrobenzene → 2-Chloro-1-fluoro-4-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloro-4-nitrobenzene | HCID 7443 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Product | 2-Chloro-1-fluoro-4-nitrobenzene | HCID 67688 | 93% |
Reaction Steps
1,500 parts of 3,4-dichloronitrobenzene, 680 parts of potassium fluoride and 5 parts of cesium fluoride are stirred in 1,500 parts of tetramethylenesulfone under nitrogen for 3 hours at 220° C. Working up takes place as described in Example 1(a). 1,275 parts (93% of theory) of 3-chloro-4-fluoronitrobenzene of melting point 41°-42° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04229365 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-54ce1f86f54c48cc9dfab5c428c9a694 |
| Source note | uspto-grants-1980_10 |