Aluminium lithium hydride → HCID 53686251, compound

HRID 903837Notes

Reaction equation

HRID 903837 reaction equation
[C:1]([C:3]12[CH2:12][CH:8]([CH2:9][CH2:10][CH2:11]1)[CH:7]1[CH2:13][CH:4]2[CH2:5][CH2:6]1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:2][CH2:1][C:3]12[CH2:12][CH:8]([CH2:9][CH2:10][CH2:11]1)[CH:7]1[CH2:13][CH:4]2[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 54315545HCID 54315545, compound

Product 1

HCID 53686251HCID 53686251, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

1.75 g (0.01 mole) of 1-cyanotricyclo[4.3.1.12,5 ]undecane in 30 ml of dry tetrahydrofuran was added dropwise to 0.45 g of lithium aluminum hydride suspended in tetrahydrofuran. After the addition, the resulting mixture was stirred under reflux for 2 hours. Thereafter, the same procedure was repeated as in Example 1 to afford 1-aminomethyltricyclo[4.3.1.12,5 ]undecane in a yield of 91%.

Workup

  1. additionAfter the addition
  2. temperatureunder reflux for 2 hours

Sources & evidence

ORD record
ord-386fc1bab1bb4fbcb41e1479be3dc17c
Source dataset
uspto-grants-1980_10
Patent number
US04229375

Reaction notes

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