Sodium Hydroxide → HCID 86737274, compound

HRID 903844Notes

Reaction equation

HRID 903844 reaction equation
[OH-:1].[Na+].Cl.[NH2:4]O.[CH2:6]([C:9]1[C:14]([CH:15]=O)=[CH:13][C:12]2[O:17][CH2:18][O:19][C:11]=2[CH:10]=1)[CH2:7][CH3:8]>O.C(O)C>[CH2:6]([C:9]1[C:14]([CH:15]=[N:4][OH:1])=[CH:13][C:12]2[O:17][CH2:18][O:19][C:11]=2[CH:10]=1)[CH2:7][CH3:8]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 157882706-Propyl-1,3-benzodioxole-5-carbaldehyde

Product 1

HCID 86737274HCID 86737274, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent2×

Procedure

21.3 g (0.533 mol) of sodium hydroxide in 27 ml of water were added to a suspension of 37.1 g (0.533 mol) of hydroxylamine hydrochloride in 500 ml of ethanol and a solution of 77.0 (0.4 mol) of 6-n-propyl-3,4-methylenedioxybenzaldehyde in 150 ml of ethanol was then added. After stirring for four hours under reflux, the reaction mixture was cooled, the solvent was stripped off and the residue was treated with water. The mixture was filtered and the residue was triturated with a mixture of petroleum ether and ether (6:1), again filtered off and dried in air. 72 g (87% of theory) of crystals of melting point 83° C. were obtained.

Workup

  1. temperatureunder reflux
  2. temperaturethe reaction mixture was cooled
  3. filtrationThe mixture was filtered
  4. customthe residue was triturated with a mixture of petroleum ether and ether (6:1)
  5. filtrationagain filtered off
  6. customdried in air
  7. custom72 g (87% of theory) of crystals of melting point 83° C. were obtained

Sources & evidence

ORD record
ord-c58e7d20bff7452980476d268f7ff69e
Source dataset
uspto-grants-1980_10
Patent number
US04229445

Reaction notes

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