Sodium Acetate → HCID 23335447, compound

HRID 903886Notes

Reaction equation

HRID 903886 reaction equation
[CH3:1][C:2]1([C:18]([OH:20])=O)[N:6]([C:7](=[O:17])[NH:8][C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[CH:10]=2)[CH2:5][CH2:4][S:3]1.C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH3:1][C:2]12[C:18](=[O:20])[N:8]([C:9]3[CH:10]=[C:11]([Cl:16])[CH:12]=[C:13]([Cl:15])[CH:14]=3)[C:7](=[O:17])[N:6]1[CH2:5][CH2:4][S:3]2

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 23335460HCID 23335460, compound

Product 1

HCID 23335447HCID 23335447, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
90 °C

Procedure

5.0 g of the thus obtained 2-methyl-3-(3,5-dichlorophenylcarbamoyl)thiazolidine-2-carboxylic acid and 5 mg of sodium acetate were added to 30 ml of acetic anhydride and heated at 90° C. for 2 hours. The reaction mixture was concentrated under reduced pressure, to which was added water. The resultant crystals were recrystallized from a mixed solvent of ethyl acetate and n-hexane to give 3.92 g of 7a-methyl-6-(3,5-dichlorophenyl)perhydroimidazo[5,1-b]thiazole-5,7-dion (Compound No. 3). The results of the elementary analysis and the melting point were as given in table 1.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, to which
  2. additionwas added water
  3. customThe resultant crystals were recrystallized from a mixed solvent of ethyl acetate and n-hexane

Sources & evidence

ORD record
ord-ad484c9ddbd24860bcd603a4bcf7b313
Source dataset
uspto-grants-1980_10
Patent number
US04229461

Reaction notes

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