Sodium Acetate → HCID 23335447, compound

Participants

Reaction Conditions

Reaction Steps

5.0 g of the thus obtained 2-methyl-3-(3,5-dichlorophenylcarbamoyl)thiazolidine-2-carboxylic acid and 5 mg of sodium acetate were added to 30 ml of acetic anhydride and heated at 90° C. for 2 hours. The reaction mixture was concentrated under reduced pressure, to which was added water. The resultant crystals were recrystallized from a mixed solvent of ethyl acetate and n-hexane to give 3.92 g of 7a-methyl-6-(3,5-dichlorophenyl)perhydroimidazo[5,1-b]thiazole-5,7-dion (Compound No. 3). The results of the elementary analysis and the melting point were as given in table 1.

Provenance & Evidence