Sodium Hydroxide → HCID 13464030, compound

HRID 903895Notes

Reaction equation

HRID 903895 reaction equation
CN1CCN([C:8]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[C:16](=[CH2:23])[C:11]3[CH:12]=[N:13][CH:14]=[CH:15][C:10]=3[CH:9]=2)CC1.[OH-:24].[Na+]>Cl>[CH2:23]=[C:16]1[C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:10]=2[CH2:9][C:8](=[O:24])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]1=2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13464029HCID 13464029, compound

Product 1

HCID 13464030HCID 13464030, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of the product from Step D (10.76 g.) and 3N HCl (150 ml.) is stirred at room temperature for approximately 24 hours. The dark brown solution is made alkaline by the addition of 20% NaOH solution and extracted with methylene chloride. The extracts are washed with H2O, saturated NaCl solution and dried (Na2SO4). Removal of the solvent in vacuo followed by trituration with petroleum ether (30°-60°) provides 6.2 g., m.p. 98°-110° C.

Workup

  1. extractionextracted with methylene chloride
  2. washThe extracts are washed with H2O, saturated NaCl solution
  3. dry with materialdried (Na2SO4)
  4. customRemoval of the solvent in vacuo
  5. customfollowed by trituration with petroleum ether (30°-60°)
  6. customprovides 6.2 g

Sources & evidence

ORD record
ord-57b7ad4a3a9a45cca407287488e4b8dd
Source dataset
uspto-grants-1980_10
Patent number
US04229455

Reaction notes

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