反应详情

A mixture of 4 parts of 1-(4-methoxyphenyl)-2-methyl-1H-imidazole and 37.5 parts of hydrobromic acid solution 48% is stirred and refluxed overnight. After cooling, the reaction mixture is evaporated. The residue is triturated in a mixture of 2-propanone and 2,2'-oxybispropane. The product is filtered off and crystallized from a mixture of ethanol and 2,2'-oxybispropane, yielding 3.8 parts (69%) of 4-(2-methyl-1H-imidazol-1-yl)phenol monohydrobromide; mp. 181-205° C.

1. temperaturerefluxed overnight
2. temperatureAfter cooling
3. customthe reaction mixture is evaporated
4. customThe residue is triturated in a mixture of 2-propanone and 2,2'-oxybispropane
5. filtrationThe product is filtered off
6. customcrystallized from a mixture of ethanol and 2,2'-oxybispropane