Hydrogen Bromide → 4-(1,2,4-Triazol-1-yl)phenol

HRID 903935Notes

Reaction equation

HRID 903935 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[N:12][CH:11]=[N:10]2)=[CH:5][CH:4]=1.Br>>[N:9]1([C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=2)[CH:13]=[N:12][CH:11]=[N:10]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 110843901-(4-methoxyphenyl)-1H-1,2,4-triazole

Product 1

HCID 1100644-(1,2,4-Triazol-1-yl)phenolYield 74%

Procedure

A mixture of 8 parts of 1-(4-methoxyphenyl)-1H-1,2,4-triazole and 150 parts of a hydrobromic acid solution 48% is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from ethanol, yielding 5.5 parts (74%) of 4-(1H-1,2,4-triazol-1-yl)phenol; mp. 255.4° C. EXAMPLE V

Workup

  1. temperaturerefluxed overnight
  2. customThe reaction mixture is evaporated
  3. customthe residue is triturated in 2-propanone
  4. filtrationThe product is filtered off
  5. customcrystallized from ethanol

Sources & evidence

ORD record
ord-a8979158c393422f808fcacbf2860b50
Source dataset
uspto-grants-1980_10
Patent number
US04229460

Reaction notes

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