Hydrochloric Acid → HCID 178492091, compound

HRID 903945Notes

Reaction equation

HRID 903945 reaction equation
[NH2:1][C:2](=[S:16])[NH:3][N:4]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:5](=O)[CH3:6].[OH-].[Na+].CO.Cl>O>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([N:4]2[C:5]([CH3:6])=[N:1][C:2]([SH:16])=[N:3]2)=[CH:9][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 54330889Acetic acid 2-(aminothioxomethyl)-1-(4-methoxyphenyl)hydrazide

Product 1

HCID 178492091HCID 178492091, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 14.5 parts of acetic acid 2-(aminothioxomethyl)-1-(4-methoxyphenyl)hydrazide, 5 parts of sodium hydroxide and 80 parts of methanol is stirred and refluxed for 30 minutes. The reaction mixture is cooled and water is added. The whole is adjusted to pH 5 with a hydrochloric acid solution. The precipitated product is filtered off and dried, yielding 12.3 parts (91%) of 1-(4-methoxyphenyl)-5-methyl-1H-1,2,4-triazole-3-thiol.

Workup

  1. temperaturerefluxed for 30 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitated product is filtered off
  4. customdried

Sources & evidence

ORD record
ord-37d95dd57f734bca8ae17b29b3441599
Source dataset
uspto-grants-1980_10
Patent number
US04229460

Reaction notes

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