Methylamine → HCID 23458432, compound

HRID 903969Notes

Reaction equation

HRID 903969 reaction equation
C([O:3][C:4]([CH2:6][O:7][CH:8]([CH:14]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[O:22][CH3:23])[C:9](OCC)=[O:10])=O)C.[CH3:30][NH2:31]>C(O)C>[CH3:23][O:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH:14]([CH:8]1[O:7][CH2:6][C:4](=[O:3])[N:31]([CH3:30])[C:9]1=[O:10])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23458293HCID 23458293, compound

Product 1

HCID 23458432HCID 23458432, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4 g of ethyl 2-ethoxycarbonylmethyloxy-3-phenyl-3(2-methoxyphenoxy)propionate dissolved in 30 ml of ethanol was heated in an autoclave at 150° C. for 20 hours with 20 ml of a 10% ethanolic solution of methylamine. Cooling was allowed to take place and the solvent was removed under reduced pressure. The residue was crystallized from ethanol to obtain 2.26 g of 2-[α-(2-methoxy-phenoxy)-benzyl]-4-methyl-morpholin-3,5-dione.

Workup

  1. temperatureCooling
  2. customthe solvent was removed under reduced pressure
  3. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-4cf9b8ac598b4d3483b322008d6e796e
Source dataset
uspto-grants-1980_10
Patent number
US04229449

Reaction notes

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