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HRID904082

反应详情

EQUATION

反应方程式

HRID 904082 的结构方程式

REACTANTS

反应物

2
结构：CN(C)S(=O)(=O)Cl
HCID83372

Dimethylsulphamoyl chloride

C2H6ClNO2S

结构：CNc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
HCID805015

1,1,1,3,3,3-Hexafluoro-2-(4-(methylamino)phenyl)propan-2-ol

C10H9F6NO

PRODUCTS

生成物

1
结构：CN(C)S(=O)(=O)N(C)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
HCID20704038

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

To 5.4 g (20 mmole) N-methyl-4-(hexafluoro-2-hydroxy-2-propyl)aniline in 50 ml pyridine add 4.3 g (30 mmole) dimethylsulfamoyl chloride. Stir 16 hours, pour onto water, acidify and extract with Et2O. Wash with 1N NaOH, acidify the aqueous layer, and extract with Et2O. Dry, concentrate and recrystallize first from CCl4, and then from Et2O-hexane to obtain the product; m.p. 63°-65° C.

WORKUP

后处理

  1. additionpour onto water
  2. extractionextract with Et2O
  3. washWash with 1N NaOH
  4. extractionextract with Et2O
  5. customDry
  6. concentrationconcentrate
  7. customrecrystallize first from CCl4
  8. customfrom Et2O-hexane to obtain the product