HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[4-(hexafluoro-2-hydroxy-2-propyl)phenyl]-N'-ethylsulfamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol | HCID 577801 | — |
| Reactant | Ethylsulfamoyl chloride | HCID 11040810 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-[4-(hexafluoro-2-hydroxy-2-propyl)phenyl]-N'-ethylsulfamide | HCID 54217972 | — |
Reaction Steps
To 5.18 g (20 mmole) 4-(hexafluoro-2-hydroxy-2-propyl)aniline and 3.44 g (24 mmole) N-ethylsulfamoyl chloride in 30 ml CHCl3, add 2.18 g (24 mmole) Et3N in 20 ml CHCl3 and stir for 16 hours. Dilute with CHCl3 and wash with 1N HCl. Dry, concentrate and recrystallize from Et2O-hexane to yield the product; m.p. 178°-179° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230635 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-8f69a1c90b034d4ab2299814b7828bae |
| Source note | uspto-grants-1980_10 |