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HRID904083

反应详情

EQUATION

反应方程式

HRID 904083 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
HCID577801

2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

C9H7F6NO

结构：CCNS(=O)(=O)Cl
HCID11040810

ethylsulfamoyl chloride

C2H6ClNO2S

PRODUCTS

生成物

1
结构：CCNS(=O)(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1
HCID54217972

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

3 次

PROCEDURE

实验过程

To 5.18 g (20 mmole) 4-(hexafluoro-2-hydroxy-2-propyl)aniline and 3.44 g (24 mmole) N-ethylsulfamoyl chloride in 30 ml CHCl3, add 2.18 g (24 mmole) Et3N in 20 ml CHCl3 and stir for 16 hours. Dilute with CHCl3 and wash with 1N HCl. Dry, concentrate and recrystallize from Et2O-hexane to yield the product; m.p. 178°-179° C.

WORKUP

后处理

  1. washwash with 1N HCl
  2. customDry
  3. concentrationconcentrate
  4. customrecrystallize from Et2O-hexane
  5. customto yield the product