HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Acetamido-4'-(hexafluoro-2-hydroxy-2-propyl)benzenesulfonanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-Acetylsulfanilyl chloride | HCID 8481 | — |
| Reactant | 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol | HCID 577801 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-Acetamido-4'-(hexafluoro-2-hydroxy-2-propyl)benzenesulfonanilide | HCID 23333497 | — |
Reaction Steps
To 8.5 g (36 mmole) 4-(hexafluoro-2-hydroxy-2-propyl)aniline in 30 ml pyridine, add 7.8 g (30 mmole) N-acetylsulfanilyl chloride. Stir 2 hours, pour onto ice and acidify with concentrated HCl. Extract with Et2O, and wash this with 1N NaOH. Acidify the aqueous layer, extract with Et2O and dry and concentrate. Recrystallize from Et2O-hexane to give the product; m.p. 198°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04230635 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-8accf66319074438b47c2d124d5a8af6 |
| Source note | uspto-grants-1980_10 |