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HRID904084

反应详情

EQUATION

反应方程式

HRID 904084 反应方程式

REACTANTS

反应物

3
Hydrochloric Acid 分子结构式
HCID313

Hydrochloric Acid

ClH

4-(Acetylamino)benzenesulfonyl chloride 分子结构式
HCID8481

4-(Acetylamino)benzenesulfonyl chloride

C8H8ClNO3S

2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 分子结构式
HCID577801

2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

C9H7F6NO

PRODUCTS

产物

1
HCID 23333497 分子结构式
HCID23333497

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
Pyridine 分子结构式
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

To 8.5 g (36 mmole) 4-(hexafluoro-2-hydroxy-2-propyl)aniline in 30 ml pyridine, add 7.8 g (30 mmole) N-acetylsulfanilyl chloride. Stir 2 hours, pour onto ice and acidify with concentrated HCl. Extract with Et2O, and wash this with 1N NaOH. Acidify the aqueous layer, extract with Et2O and dry and concentrate. Recrystallize from Et2O-hexane to give the product; m.p. 198°-200° C.

WORKUP

后处理

  1. additionpour onto ice
  2. extractionExtract with Et2O
  3. washwash this with 1N NaOH
  4. extractionextract with Et2O
  5. customdry
  6. concentrationconcentrate
  7. customRecrystallize from Et2O-hexane
  8. customto give the product