Water → HCID 23333511, compound

HRID 904086Notes

Reaction equation

HRID 904086 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([C:9]1[CH:15]=[C:14]([CH3:16])[C:12]([NH2:13])=[C:11]([O:17][CH3:18])[CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].[CH3:21][S:22](Cl)(=[O:24])=[O:23].O>N1C=CC=CC=1>[F:1][C:2]([F:19])([F:20])[C:3]([C:9]1[CH:15]=[C:14]([CH3:16])[C:12]([NH:13][S:22]([CH3:21])(=[O:24])=[O:23])=[C:11]([O:17][CH3:18])[CH:10]=1)([OH:8])[C:4]([F:6])([F:5])[F:7]

Participants

5

Reactant 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 54083180HCID 54083180, compound

Product 1

HCID 23333511HCID 23333511, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 4.54 g (15 mmole) 4-(hexafluoro-2-hydroxy-2-propyl)-2-methoxy-6-methylaniline in 25 ml pyridine, add 1.94 g (17 mmole) methanesulfonyl chloride. After 16 hours, pour onto 200 ml H2O and filter the solid. Recrystallize from Et2O-hexane to obtain the product; m.p. 109°-110° C.

Workup

  1. filtrationfilter the solid
  2. customRecrystallize from Et2O-hexane
  3. customto obtain the product

Sources & evidence

ORD record
ord-880adc1264a048aea6edf25b1a74d732
Source dataset
uspto-grants-1980_10
Patent number
US04230635

Reaction notes

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