Hydrochloric Acid → HCID 86737289, compound

HRID 904090Notes

Reaction equation

HRID 904090 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](O)([C:14]([F:17])([F:16])[Cl:15])[C:10]([F:13])([F:12])[Cl:11])=[CH:5][CH:4]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21].Cl>N1C=CC=CC=1>[CH3:1][N:2]([S:20]([CH3:19])(=[O:22])=[O:21])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:14]([F:17])([F:16])[Cl:15])[C:10]([F:13])([F:12])[Cl:11])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 53904284HCID 53904284, compound

Product 1

HCID 86737289HCID 86737289, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 6.1 g (20 mmole) N-methyl-4-(1,3-dichlorotetrafluoro-2-hydroxy-2-propyl)aniline in 30 ml pyridine add 3.4 g (30 mmole) methanesulfonyl chloride. Stir 1.5 hours, pour onto water, acidify with concentrated HCl and filter. Dissolve the solid in 1N NaOH, wash with Et2O, acidify and filter. Recrystallize the solid from Et2O-hexane to give the product; m.p. 140°-142° C.

Workup

  1. additionpour onto water
  2. filtrationfilter
  3. dissolutionDissolve the solid in 1N NaOH
  4. washwash with Et2O
  5. filtrationfilter
  6. customRecrystallize the solid from Et2O-hexane
  7. customto give the product

Sources & evidence

ORD record
ord-344f9741f3604c86a33d3c0f6fd180a4
Source dataset
uspto-grants-1980_10
Patent number
US04230635

Reaction notes

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