Phosphorus oxychloride → 3-Chloro-4-methyl-6-phenylpyridazine

HRID 904128노트

반응식

HRID 904128 반응식
[CH3:1][C:2]1[C:3](=O)[NH:4][N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:3]1[N:4]=[N:5][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:7][C:2]=1[CH3:1]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 833194-Methyl-6-phenylpyridazin-3(2H)-one

생성물 1

HCID 1199993-Chloro-4-methyl-6-phenylpyridazine

실험 절차

A mixture of 13.2 g. of 4-methyl-6-phenyl-3(2H)-pyridazinone and 200 ml. of phosphorus oxychloride is heated on a steam bath for 18 hours. The reaction mixture is filtered. The filtrate is concentrated free of excess phosphorus oxychloride. The residue is stirred with ice water and filtered. The solid is washed with water and air dried giving 3-chloro-4-methyl-6-phenylpyridazine as a cream colored solid.

후처리

  1. additionA mixture of 13.2 g
  2. filtrationThe reaction mixture is filtered
  3. concentrationThe filtrate is concentrated free of excess phosphorus oxychloride
  4. filtrationfiltered
  5. washThe solid is washed with water and air
  6. customdried

출처 및 근거

ORD 기록
ord-9321a85787724d45844918e9993f8e52
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230705

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