Phosphorus oxychloride → 3-Chloro-4-methyl-6-phenylpyridazine

HRID 904128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 904128
[CH3:1][C:2]1[C:3](=O)[NH:4][N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:3]1[N:4]=[N:5][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:7][C:2]=1[CH3:1]

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 833194-Methyl-6-phenylpyridazin-3(2H)-one

Produkt 1

HCID 1199993-Chloro-4-methyl-6-phenylpyridazine

Versuchsvorschrift

A mixture of 13.2 g. of 4-methyl-6-phenyl-3(2H)-pyridazinone and 200 ml. of phosphorus oxychloride is heated on a steam bath for 18 hours. The reaction mixture is filtered. The filtrate is concentrated free of excess phosphorus oxychloride. The residue is stirred with ice water and filtered. The solid is washed with water and air dried giving 3-chloro-4-methyl-6-phenylpyridazine as a cream colored solid.

Aufarbeitung

  1. additionA mixture of 13.2 g
  2. filtrationThe reaction mixture is filtered
  3. concentrationThe filtrate is concentrated free of excess phosphorus oxychloride
  4. filtrationfiltered
  5. washThe solid is washed with water and air
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9321a85787724d45844918e9993f8e52
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04230705

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