反应详情

A mixture of 13.2 g. of 4-methyl-6-phenyl-3(2H)-pyridazinone and 200 ml. of phosphorus oxychloride is heated on a steam bath for 18 hours. The reaction mixture is filtered. The filtrate is concentrated free of excess phosphorus oxychloride. The residue is stirred with ice water and filtered. The solid is washed with water and air dried giving 3-chloro-4-methyl-6-phenylpyridazine as a cream colored solid.

1. additionA mixture of 13.2 g
2. filtrationThe reaction mixture is filtered
3. concentrationThe filtrate is concentrated free of excess phosphorus oxychloride
4. filtrationfiltered
5. washThe solid is washed with water and air
6. customdried