反应详情

温度

90 °C

A mixture of 2.7 g (11.6 mM) of the phenyl ester of tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene carbamic acid 8 and 10.0 g (106 mM) of 2-aminopyridine was heated at 90° C. for 1 hr. The excess amine was removed by vacuum distillation and the residue triturated with 35 ml. ethanol, filtered and the collected solid recrystallized from ethyl acetate to give 1.1 g of the above urea as a cream colored solid, m.p. 218° C. (dec.).

1. customThe excess amine was removed by vacuum distillation
2. customthe residue triturated with 35 ml
3. filtrationethanol, filtered
4. customthe collected solid recrystallized from ethyl acetate