2-Aminopyridine → 1-(2-Pyridinyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.7 g (11.6 mM) of the phenyl ester of tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene carbamic acid 8 and 10.0 g (106 mM) of 2-aminopyridine was heated at 90° C. for 1 hr. The excess amine was removed by vacuum distillation and the residue triturated with 35 ml. ethanol, filtered and the collected solid recrystallized from ethyl acetate to give 1.1 g of the above urea as a cream colored solid, m.p. 218° C. (dec.).

Provenance & Evidence