HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 904157Generated: October 31, 2026
Water → 1-(3-methyl-5-oxo-4H-imidazol-2-yl)-3-(6-oxo-1H-pyridin-2-yl)urea
https://huagongshe.com/reaction/904157
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene carbamic acid | HCID 136469822 | — |
| Reactant | 2-Amino-6-hydroxypyridine | HCID 178507634 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-methyl-5-oxo-4H-imidazol-2-yl)-3-(6-oxo-1H-pyridin-2-yl)urea | HCID 178481147 | 29.5% |
Reaction Steps
A mixture of 3.0 g (12.8 mM) of the phenyl carbamate 8 and 1.5 g (12.8 mM) of 2-amino-6-hydroxypyridine in 25 ml of anhydrous DMF was heated at 85° C. for 5 hrs., cooled, and poured into 100 ml of water. The resulting precipitate was collected, washed successively with water, ethanol, ethyl acetate, and ether. Recrystallization from ethanol gave 1.0 g of the above urea as a yellow solid, m.p. 233°-234° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04230713 |
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| Source dataset | uspto-grants-1980_10 |
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| ORD ID | ord-ecb519eb07b84e7ba671f123b3c517f8 |
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| Source note | uspto-grants-1980_10 |
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