反应详情

The starting material employed above had been synthesized in the same manner as described in Example 1. That is, N-methyl-3-ethoxycarbonylmethylaniline (20.7 g), sodium hydrogencarbonate (19 g), water (30 ml) and ethyl 2-bromomethylbenzoate (27.5 g) were used to produce N-methyl-N-(2-ethoxycarbonylbenzyl)-3-ethoxycarbonylmethylaniline (26 g) as a light yellow oil. Then, N-methyl-N-(2-ethoxycarbonylbenzyl)-3-ethoxycarbonylmethylaniline (26 g) so produced, sodium hydroxide (40 g), water (450 ml) and ethanol (150 ml) were used to prepare N-methyl-N-(2-carboxybenzyl)-3-carboxymethylaniline (14.8 g).

1. customabove had been synthesized in the same manner