反应详情

N-methyl-4-ethoxycarbonylmethylaniline (5.8 g) and 2-trichloromethyl-5-chlorobenzylbromide (9.7 g) were dissolved in acetone (50 g), and anhydrous potassium carbonate (4.2 g) was added to the solution. The mixture was heated for 3 days with stirring. Then, the inorganic material was removed by filtration, and the solvent was distilled off. The residue was purified by liquid chromatography using a silica gel column to obtain N-methyl-N-(2-trichloromethyl-5-chlorobenzyl)-4-ethoxycarbonylmethylaniline (6.5 g).

1. temperatureThe mixture was heated for 3 days
2. customThen, the inorganic material was removed by filtration
3. distillationthe solvent was distilled off
4. customThe residue was purified by liquid chromatography