Acetyl chloride → HCID 23333627, compound

HRID 904201Notes

Reaction equation

HRID 904201 reaction equation
[CH2:1]([N:8]1[CH2:14][C:13]2[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=2[C:11](=[O:19])[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:28](Cl)(=[O:30])[CH3:29]>C(Cl)Cl>[C:28]([C:21]1[CH:22]=[CH:23][C:9]2[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:14][C:13]3[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=3[C:11](=[O:19])[C:10]=2[CH:20]=1)(=[O:30])[CH3:29]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 21814004HCID 21814004, compound

Product 1

HCID 23333627HCID 23333627, compoundYield 14.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5,6-Dihydro-5-benzyl-11-oxodibenz[b,e]azepine (6.2 g), anhydrous aluminum chloride (6.07 g), acetyl chloride (4.87 g) and methylene chloride (60 ml) were treated in the same manner as described in Example 25 to obtain the desired compound (1.03 g).

Sources & evidence

ORD record
ord-ac786e08985b4542a6973fb3ed29c766
Source dataset
uspto-grants-1980_10
Patent number
US04230703

Reaction notes

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