Hydrochloric Acid → HCID 70550884, compound

HRID 904222Notes

Reaction equation

HRID 904222 reaction equation
C([N:3]1[CH2:21][CH2:20][C@@:10]23[C:11]4[CH:12]=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][C:16]=4[CH2:17][C@@H:4]1[C@@H:5]2[CH2:6][C@H:7]([CH3:23])[C:8](=[O:22])[CH2:9]3)#N.[ClH:24]>>[ClH:24].[CH3:19][O:18][C:13]1[CH:14]=[CH:15][C:16]2[CH2:17][C@H:4]3[NH:3][CH2:21][CH2:20][C@@:10]4([C:11]=2[CH:12]=1)[C@H:5]3[CH2:6][C@H:7]([CH3:23])[C:8](=[O:22])[CH2:9]4

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86737295HCID 86737295, compound

Product 1

HCID 70550884HCID 70550884, compound

Procedure

A suspension of 10 (7.2 g, 23 mmol) in 2 N HCl was refluxed for 5 hours. The clear solution was evaporated to give 7.4 g of 13 as a foam, homogeneous by thin layer chromatography, which was used without further purification in the alkylation reactions as described below.

Workup

  1. temperaturewas refluxed for 5 hours
  2. customThe clear solution was evaporated

Sources & evidence

ORD record
ord-faf9df66a3764f28b9ac380b5f5ddf50
Source dataset
uspto-grants-1980_10
Patent number
US04230712

Reaction notes

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