Hydrochloric Acid → HCID 70550824, compound

HRID 904223Notes

Reaction equation

HRID 904223 reaction equation
C([N:3]1[CH2:21][CH2:20][C@@:10]23[C:11]4[CH:12]=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][C:16]=4[CH2:17][C@@H:4]1[C@@H:5]2[C@@H:6]([CH2:24][CH3:25])[C@H:7]([CH3:23])[C:8](=[O:22])[CH2:9]3)#N.[ClH:26]>>[ClH:26].[CH2:24]([C@@H:6]1[C@@H:5]2[C@:10]3([CH2:20][CH2:21][NH:3][C@@H:4]2[CH2:17][C:16]2[CH:15]=[CH:14][C:13]([O:18][CH3:19])=[CH:12][C:11]3=2)[CH2:9][C:8](=[O:22])[C@H:7]1[CH3:23])[CH3:25]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86737294HCID 86737294, compound

Product 1

HCID 70550824HCID 70550824, compound

Procedure

Compound 12 (10.6 g, 32.4 mmol) and 2 N HCl (200 ml) was refluxed for 5 hours and the resulting solution evaporated to dryness. Upon coevaporation with ethanol, there was obtained 6.9 g (63%) of crystalline 15, mp>265°.

Workup

  1. customthe resulting solution evaporated to dryness
  2. customUpon coevaporation with ethanol, there was obtained 6.9 g (63%) of crystalline 15, mp>265°

Sources & evidence

ORD record
ord-d0595e941c9d4f6bbbfe10ca9919a06d
Source dataset
uspto-grants-1980_10
Patent number
US04230712

Reaction notes

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