反应详情

To a solution of 39.2 g of 2-(4-iodophenyl)propionaldehyde in 39.2 ml of methanol was added 0.2 g of p-toluenesulfonic acid, and the mixture was stirred for 10 minutes. After addition of 19.2 g of methyl orthoformate, stirring was continued for 30 minutes. After completion of the reaction, 1.0 g of sodium methylate was added to the reaction mixture and the solvent was removed by distillation under reduced pressure. On distillation of the residue, there was obtained 43.2 g of 2-(4-iodophenyl)propionaldehyde dimethyl acetal, b.p. 155°-160° C./15 mmHg.

1. stirringstirring
2. waitwas continued for 30 minutes
3. additionwas added to the reaction mixture
4. customthe solvent was removed by distillation under reduced pressure
5. distillationOn distillation of the residue