反应详情

A mixture of 4.4 g. of ethyl 4-(2-sulfoethylamino)benzoate, 2.3 g. of potassium hydroxide, 10 ml. of water, and 90 ml. of ethanol is stirred under reflux for 8 hours, allowed to cool, diluted with water, and brought to pH 4 with concentrated hydrochloric acid. The precipitate is collected by filtration, dried, and recrystallized from acetic acid to yield 4-(2-sulfoethylamino)benzoic acid as a white solid.

1. additionA mixture of 4.4 g
2. temperatureunder reflux for 8 hours
3. temperatureto cool
4. filtrationThe precipitate is collected by filtration
5. customdried
6. customrecrystallized from acetic acid