3-Morpholino-2-methyl-1-chloropropane hydrochloride → 4-(3'-Morpholino-2'-methylpropoxy)-3-phenyl-coumarin

HRID 904299Notes

Reaction equation

HRID 904299 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl.[O:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH:27]([CH3:30])[CH2:28]Cl)[CH2:22][CH2:21]1>>[O:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH:27]([CH3:30])[CH2:28][O:1][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[O:5][C:4](=[O:12])[C:3]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 233340923-Morpholino-2-methyl-1-chloropropane hydrochlorideHCID 54688870Coumarin, 4-hydroxy-3-phenyl-

Product 1

HCID 233340994-(3'-Morpholino-2'-methylpropoxy)-3-phenyl-coumarinYield 82.5%

Procedure

This compound is prepared according to the method of Example 8 from 14.3 g. (0.06 mol) of 4-hydroxy-3-phenyl-coumarin and 16.7 g. (0.078 mol) of 3-morpholino-2-methyl-1-chloropropane hydrochloride. After recrystallisation from ethanol, 18.8 g. are obtained. Yield 82.5% (theoretical yield 22.8 g.); M.P. 113° C.

Workup

  1. customThis compound is prepared
  2. customAfter recrystallisation from ethanol, 18.8 g
  3. customare obtained

Sources & evidence

ORD record
ord-4628ae02c8ec4a1296b59c0c76c6dc5d
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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