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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 904299Generated: October 30, 2026

3-Morpholino-2-methyl-1-chloropropane hydrochloride → 4-(3'-Morpholino-2'-methylpropoxy)-3-phenyl-coumarin

https://huagongshe.com/reaction/904299

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Morpholino-2-methyl-1-chloropropane hydrochlorideHCID 23334092—
ReactantCoumarin, 4-hydroxy-3-phenyl-HCID 54688870—
Product4-(3'-Morpholino-2'-methylpropoxy)-3-phenyl-coumarinHCID 2333409982.5%

Reaction Steps

This compound is prepared according to the method of Example 8 from 14.3 g. (0.06 mol) of 4-hydroxy-3-phenyl-coumarin and 16.7 g. (0.078 mol) of 3-morpholino-2-methyl-1-chloropropane hydrochloride. After recrystallisation from ethanol, 18.8 g. are obtained. Yield 82.5% (theoretical yield 22.8 g.); M.P. 113° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04230850
Source datasetuspto-grants-1980_10
ORD IDord-4628ae02c8ec4a1296b59c0c76c6dc5d
Source noteuspto-grants-1980_10