4-(2-Chloroethyl)morpholine → HCID 23334083, compound

HRID 904310Notes

Reaction equation

HRID 904310 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10](=[O:20])[O:11][C:12]3[C:17]([C:18]=2[OH:19])=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:5][CH:4]=1.[O:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28]Cl)[CH2:23][CH2:22]1>>[O:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][O:19][C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[O:11][C:10](=[O:20])[C:9]=2[C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 54690405HCID 54690405, compound

Product 1

HCID 23334083HCID 23334083, compoundYield 82.5%

Procedure

Obtained according to the method of Example 8, from 12.1 g. (0.045 mol) of 3-(4'-methoxyphenyl)-4-hydroxy-coumarin and 8.7 g. (0.058 mol) of 2-morpholino-1-chlorethane. After recrystallisation from ethanol, there are obtained 14.7 g. of a beige product; M.P. 104° C. Yield 82.5% (theoretical yield 17.1 g.).

Workup

  1. customObtained
  2. customAfter recrystallisation from ethanol, there
  3. customare obtained 14.7 g

Sources & evidence

ORD record
ord-f6e12b9afbd94aec806cdacb724386ae
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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