HCID 19907059, compound → HCID 23334037, compound

HRID 904315Notes

Reaction equation

HRID 904315 reaction equation
[OH:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[O:5][C:4](=[O:12])[C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[O:19]1[CH2:24][CH2:23][N:22]([CH2:25][C:26]([CH3:29])(Cl)[CH3:27])[CH2:21][CH2:20]1>>[O:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH:26]([CH3:29])[CH2:27][O:1][C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[O:5][C:4](=[O:12])[C:3]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 19907059HCID 19907059, compoundHCID 547213304-Hydroxy-3-phenyl-5,6,7,8-tetrahydrocoumarin

Product 1

HCID 23334037HCID 23334037, compoundYield 83.5%

Procedure

Prepared as indicated in Example 14, Stage B, from 29 g. (0.12 mol) of 4-hydroxy-3-phenyl-5,6,7,8-tetrahydrocoumarin and 27.3 g. (0.156 mol) of 3-morpholino-2-methyl-2-chloropropane. 38.2 g. of an oil which cannot be crystallised are obtained. Yield 83.5% (theoretical yield 45.6 g.).

Workup

  1. customPrepared
  2. customof an oil which cannot be crystallised
  3. customare obtained

Sources & evidence

ORD record
ord-1eb126b3a9d74bf8b8ca4b90cd39c874
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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