4-(3-Chloro-2-methylpropyl)morpholine → 4-(3'-Morpholino-2-methylpropoxy)-3-phenyl-6-tert.butyl-5,6,7,8-tetrahydro-coumarin

HRID 904320Notes

Reaction equation

HRID 904320 reaction equation
[OH:1][C:2]1[C:11]2[CH2:10][CH:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:8][CH2:7][C:6]=2[O:5][C:4](=[O:16])[C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[O:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH:30]([CH3:33])[CH2:31]Cl)[CH2:25][CH2:24]1>>[O:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH:30]([CH3:33])[CH2:31][O:1][C:2]2[C:11]3[CH2:10][CH:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:8][CH2:7][C:6]=3[O:5][C:4](=[O:16])[C:3]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 233340474-(3-Chloro-2-methylpropyl)morpholineHCID 572291294-Hydroxy-3-phenyl-6-tert.butyl-5,6,7,8-tetrahydro-coumarin

Product 1

HCID 867372984-(3'-Morpholino-2-methylpropoxy)-3-phenyl-6-tert.butyl-5,6,7,8-tetrahydro-coumarin

Procedure

Prepared according to the method of Example 9 from 12.8 g. (0.043 mol) of 4-hydroxy-3-phenyl-6-tert.butyl-5,6,7,8-tetrahydro-coumarin and 10.7 g. (0.061 mol) of 3-morpholino-2-methyl-1-chloropropane. The product is a thick oil which cannot be crystallised.

Workup

  1. customPrepared
  2. customcannot be crystallised

Sources & evidence

ORD record
ord-06a6d6ec6d294c1e84350f8d517dd94b
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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