4-(3-Chloro-2-methylpropyl)morpholine → 3,8-Diphenyl-4-(3'-morpholino-2'-methylpropoxy)-5,6,7,8-tetrahydrocoumarin

HRID 904322Notes

Reaction equation

HRID 904322 reaction equation
[C:1]1([C:7]2[C:8](=[O:24])[O:9][C:10]3[CH:11]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH2:12][CH2:13][CH2:14][C:15]=3[C:16]=2[OH:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:26][CH:27]([CH3:35])[CH2:28][N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[C:1]1([C:7]2[C:8](=[O:24])[O:9][C:10]3[CH:11]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:12][CH2:13][CH2:14][C:15]=3[C:16]=2[O:17][CH2:26][CH:27]([CH3:35])[CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 233340474-(3-Chloro-2-methylpropyl)morpholineHCID 547213313,8-Diphenyl-4-hydroxy-5,6,7,8-tetrahydrocoumarin

Product 1

HCID 233340293,8-Diphenyl-4-(3'-morpholino-2'-methylpropoxy)-5,6,7,8-tetrahydrocoumarinYield 35%

Procedure

Prepared according to the method of Example 9 from 3,8-diphenyl-4-hydroxy-5,6,7,8-tetrahydrocoumarin and 1-chloro-2-methyl-3-morpholino-propane. A thick, brown oil is obtained which cannot be crystallised. Yield 35%.

Workup

  1. customPrepared
  2. customA thick, brown oil is obtained which
  3. customcannot be crystallised

Sources & evidence

ORD record
ord-0d3ea203e0764e4f96f0b412e4d683a7
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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