4-(3-Chloro-2-methylpropyl)morpholine → 4-(3'-Morpholino-2'-methylpropoxy)-3,8-diphenyl-coumarin

HRID 904328Notes

Reaction equation

HRID 904328 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:18])[C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[O:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH:32]([CH3:35])[CH2:33]Cl)[CH2:27][CH2:26]1>>[O:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH:32]([CH3:35])[CH2:33][O:1][C:2]2[C:11]3[C:6](=[C:7]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:8]=[CH:9][CH:10]=3)[O:5][C:4](=[O:18])[C:3]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 233340474-(3-Chloro-2-methylpropyl)morpholineHCID 546888694-hydroxy-3,8-diphenyl-2H-chromen-2-one

Product 1

HCID 233340884-(3'-Morpholino-2'-methylpropoxy)-3,8-diphenyl-coumarinYield 69.1%

Procedure

Prepared according to the method of Example 8, by alkylation of 4-hydroxy-3,8-diphenyl-coumarin with 3-morpholino-2-methyl-1-chloropropane. After recrystallisation from ethanol, a solid melting at 120°-121° C. is obtained. Yield 69.1%.

Workup

  1. customPrepared
  2. customAfter recrystallisation from ethanol

Sources & evidence

ORD record
ord-7df5728bec874eb1a472d5ecd0c9dfc7
Source dataset
uspto-grants-1980_10
Patent number
US04230850

Reaction notes

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