Acetic Acid → HCID 20285748, compound

HRID 904458Notes

Reaction equation

HRID 904458 reaction equation
[CH3:1][C:2]1[S:3][C:4]([Cl:8])=[C:5](C)[CH:6]=1.C=O.[ClH:11].[C:12](O)(=O)[CH3:13]>>[CH3:1][C:2]1[S:3][C:4]([Cl:8])=[C:12]([CH3:13])[C:6]=1[CH2:5][Cl:11]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 12875260HCID 12875260, compound

Product 1

HCID 20285748HCID 20285748, compound

Procedure

3.04 G. of 2,4-dimethyl-5-chloro-thiophene are dissolved in 60 ml. of acetic acid and 2.1 g. of formalin and 32 ml. of concentrated hydrochloric acid are added. The mixture is stirred at room temperature for 2 hours, then poured into ice water and extracted with hexane. The organic solution is washed with 5% sodium bicarbonate solution, dried, filtered and evaporated to yield 2,4-dimethyl-3-chloromethyl-5-chloro-thiophene.

Workup

  1. extractionextracted with hexane
  2. washThe organic solution is washed with 5% sodium bicarbonate solution
  3. customdried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-7cd736743ad347bf9a44fdb925b8f41c
Source dataset
uspto-grants-1980_10
Patent number
US04230872

Reaction notes

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