Ethyl 2-amino-4,5-dimethyl3-thenoate → HCID 12862356, compound

HRID 904510Notes

Reaction equation

HRID 904510 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:13])=[C:5]([CH3:12])[C:6]=1[C:7]([O:9]CC)=O.Cl[C:15]1[N:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[CH:17][CH:16]=1>>[CH3:13][C:4]1[S:3][C:2]2[N:1]=[C:15]3[CH:16]=[CH:17][C:18]([C:21]([OH:23])=[O:22])=[CH:19][N:20]3[C:7](=[O:9])[C:6]=2[C:5]=1[CH3:12]

Participants

3

Reactant 2

HCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoateHCID 792226-Chloronicotinic acid

Product 1

HCID 12862356HCID 12862356, compoundYield 1.8%

Procedure

From 8.0 g (0.04 mol) of 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid, ethyl ester (Chemische Berichte, Vol 99, pages 94-100, 1966) and 6.3 g (0.04 mol) of 6-chloro-3-pyridinecarboxylic acid (Aldrich Chemical Company) following the procedure of Example 3, there is obtained 0.2 g of 2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid; mp 364°-368° C. after recrystallization from pyridine.

Sources & evidence

ORD record
ord-555cf99d1b60407b91e789a08433e10f
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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