Phosphorus oxychloride → HCID 12862370, compound

HRID 904532Notes

Reaction equation

HRID 904532 reaction equation
[CH2:1]([C:3]1[S:19][C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][C:13]([C:16]([NH2:18])=O)=[CH:12][N:9]3[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[S:19][C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][C:13]([C:16]#[N:18])=[CH:12][N:9]3[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 12862363HCID 12862363, compound

Product 1

HCID 12862370HCID 12862370, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

From 1.3 g (0.0048 mol) of 2-ethyl-4-oxo-4H-pyrido[1,2-a]-thieno[2,3-d]pyrimidine-7-carboxamide (Example 22), 30 ml of phosphorus oxychloride and 30 ml of chloroform and refluxing on a steam bath for six hours, following the procedure of Example 27, there is obtained 1.18 g of 2-ethyl-4-oxo-4H-pyrido[1,2-a]-thieno[2,3-d]pyrimidine-7-carbonitrile; mp 223°-224° C. after recrystallization from glacial acetic acid.

Sources & evidence

ORD record
ord-cccae0a5aaab4e3b857a567a6c7b0062
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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