Phosphorus oxychloride → HCID 12862373, compound

HRID 904534Notes

Reaction equation

HRID 904534 reaction equation
[CH2:1]([C:5]1[S:21][C:8]2[N:9]=[C:10]3[CH:17]=[CH:16][C:15]([C:18]([NH2:20])=O)=[CH:14][N:11]3[C:12](=[O:13])[C:7]=2[CH:6]=1)[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[CH2:1]([C:5]1[S:21][C:8]2[N:9]=[C:10]3[CH:17]=[CH:16][C:15]([C:18]#[N:20])=[CH:14][N:11]3[C:12](=[O:13])[C:7]=2[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 12862366HCID 12862366, compound

Product 1

HCID 12862373HCID 12862373, compoundYield 55.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

From 4.0 g (0.0133 mol) of 2-butyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide (Example 24), 100 ml of phosphorus oxychloride and 100 ml of chloroform and refluxing on a steam bath for four hours, following the procedure of Example 27, there is obtained 2.1 g of 2-butyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carbonitrile; mp 216°-217° C. after recrystallization from pyridine.

Sources & evidence

ORD record
ord-24d2ec3a9cec46948075637d5e7b7bbe
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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