Phosphorus oxychloride → HCID 12862375, compound

HRID 904536Notes

Reaction equation

HRID 904536 reaction equation
[CH3:1][C:2]1[S:18][C:5]2[N:6]=[C:7]3[CH:14]=[CH:13][C:12]([C:15]([NH2:17])=O)=[CH:11][N:8]3[C:9](=[O:10])[C:4]=2[C:3]=1[CH3:19].P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[CH3:1][C:2]1[S:18][C:5]2[N:6]=[C:7]3[CH:14]=[CH:13][C:12]([C:15]#[N:17])=[CH:11][N:8]3[C:9](=[O:10])[C:4]=2[C:3]=1[CH3:19]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 12862368HCID 12862368, compound

Product 1

HCID 12862375HCID 12862375, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

From 1.0 g (0.0037 mol) of 2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide (Example 26), 50 ml of phosphorus oxychloride and 50 ml of chloroform and refluxing on a steam bath for eighteen hours, following the procedure of Example 27, there is obtained 0.89 g of 2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carbonitrile; mp 306°-307° C. after recrystallization from glacial acetic acid.

Sources & evidence

ORD record
ord-4c3dc37348d84573b1c52f52d4433379
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

Loading…