Ammonium Chloride → HCID 178438392, compound

HRID 904539Notes

Reaction equation

HRID 904539 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[S:14][C:15]([CH2:17][CH2:18][CH3:19])=[CH:16][C:3]1=2.[N-:20]=[N+:21]=[N-:22].[Na+].[Cl-].[NH4+]>CN(C)C=O>[CH2:17]([C:15]1[S:14][C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([C:12]4[NH:22][N:21]=[N:20][N:13]=4)=[CH:8][N:7]3[C:2](=[O:1])[C:3]=2[CH:16]=1)[CH2:18][CH3:19]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 12862371HCID 12862371, compound

Product 1

HCID 178438392HCID 178438392, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 0.85 g (0.0032 mol) of 4-oxo-2-propyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carbonitrile, (Example 29), 0.68 g (0.011 mol) of sodium azide and 0.62 g (0.012 mol) of ammonium chloride in 80 ml of dimethylformamide, following the procedure of Example 34, there is obtained 0.46 g of 2-propyl-7-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidin-4-one; mp 288°-292° C. (dec) after recrystallization from pyridine.

Sources & evidence

ORD record
ord-9616c4bdbb0547c7bfd1918adabee7c1
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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