Ammonium Chloride → HCID 178440584, compound

Participants

Reaction Steps

From 7 g (0.025 mol) of 2-butyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carbonitrile (Example 30), 8.45 g (0.13 mol) of sodium azide and 6.95 g (0.13 mol) of ammonium chloride in 250 ml of dimethylformamide heated at 125°-128° C. under a nitrogen atmosphere, following the procedure of Example 34, there is obtained 4.6 g of 2-butyl-7-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidin-4-one; mp 281° C. (dec) after recrystallization from dimethylformamide-methanol.

Provenance & Evidence