Ammonium Chloride → HCID 178440584, compound

HRID 904540Notes

Reaction equation

HRID 904540 reaction equation
[CH2:1]([C:5]1[S:20][C:8]2[N:9]=[C:10]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][N:11]3[C:12](=[O:13])[C:7]=2[CH:6]=1)[CH2:2][CH2:3][CH3:4].[N-:21]=[N+:22]=[N-:23].[Na+].[Cl-].[NH4+]>CN(C)C=O>[CH2:1]([C:5]1[S:20][C:8]2[N:9]=[C:10]3[CH:17]=[CH:16][C:15]([C:18]4[NH:23][N:22]=[N:21][N:19]=4)=[CH:14][N:11]3[C:12](=[O:13])[C:7]=2[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 12862373HCID 12862373, compound

Product 1

HCID 178440584HCID 178440584, compoundYield 56.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 7 g (0.025 mol) of 2-butyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carbonitrile (Example 30), 8.45 g (0.13 mol) of sodium azide and 6.95 g (0.13 mol) of ammonium chloride in 250 ml of dimethylformamide heated at 125°-128° C. under a nitrogen atmosphere, following the procedure of Example 34, there is obtained 4.6 g of 2-butyl-7-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidin-4-one; mp 281° C. (dec) after recrystallization from dimethylformamide-methanol.

Sources & evidence

ORD record
ord-03dbf08dddec42c6b8f03fd75300f452
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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