Chlorosuccinimide → HCID 12953049, compound

HRID 904558Notes

Reaction equation

HRID 904558 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][S:18][CH2:19][C:3]1=2.ClN1C(=O)CCC1=O>N1C=CC=CC=1>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2=[CH:17][S:18][CH:19]=[C:3]12

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12953041HCID 12953041, compound

Product 1

HCID 12953049HCID 12953049, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno[3,4-d]pyrimidine-7-carboxylate (2.0 g., 0.0072 mol) and N-chlorosuccinimide (0.97 g., 0.0072 mol) in pyridine (20 ml) is heated on a steam bath for 18 minutes. The reaction mixture is cooled and poured into a large volume of ice water. The precipitate is filtered, washed with water and dried. Recrystallization from ethanol gives the product (1.1 g.), mp 175°-176° C.

Workup

  1. temperatureis heated on a steam bath for 18 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitate is filtered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from ethanol
  7. customgives the product (1.1 g.), mp 175°-176° C.

Sources & evidence

ORD record
ord-bd888c56b79443caa92da7f849edea2f
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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