Chlorosuccinimide → HCID 12953057, compound

HRID 904564Notes

Reaction equation

HRID 904564 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][CH2:18][S:19][C:3]1=2.ClN1C(=O)CCC1=O>N1C=CC=CC=1>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH:17]=[CH:18][S:19][C:3]1=2

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12953045HCID 12953045, compound

Product 1

HCID 12953057HCID 12953057, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno[3,2-d]pyrimidine-7-carboxylate (0.4 g, 0.0014 mol) and N-chlorosuccinimide (0.9 g., 0.0014 mol) in pyridine (4 ml) is heated on a steam bath for 18 minutes. The reaction mixture is cooled and poured into a large volume of ice water. The precipitate is filtered, washed with water and dried. Recrystallization from ethanol gives the product (0.2 g.) mp 188°-190° C.

Workup

  1. temperatureis heated on a steam bath for 18 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitate is filtered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from ethanol
  7. customgives the product (0.2 g.) mp 188°-190° C.

Sources & evidence

ORD record
ord-85bd004a542a4b2c8ecbfa498fa467b4
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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