Ammonium Chloride → HCID 178515251, compound

HRID 904571Notes

Reaction equation

HRID 904571 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2=[CH:14][S:15][CH:16]=[C:3]12.[N-:17]=[N+:18]=[N-:19].[Na+].[Cl-].[NH4+]>CN(C)C=O>[NH:17]1[C:12]([C:9]2[CH:10]=[CH:11][C:6]3[N:7]([CH:8]=2)[C:2](=[O:1])[C:3]2[C:4](=[CH:14][S:15][CH:16]=2)[N:5]=3)=[N:13][N:19]=[N:18]1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 12953070HCID 12953070, compound

Product 1

HCID 178515251HCID 178515251, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 10-oxo-10H-pyrido[1,2-a]thieno[3,4-d]pyrimidine-7-carbonitrile (0.058 g., 0.0003 mol), sodium azide (0.074 g., 0.0011 mol) and ammonium chloride (0.061 g., 0.0011 mol) in dimethylformamide (15 ml) is heated at 95°-100° C. under nitrogen for 46 hours. The solvent is evaporated. The residue is triturated with 1 N hydrochloric acid, filtered and sucked dry to give the product, mp 300° C. (dec).

Workup

  1. temperatureis heated at 95°-100° C. under nitrogen for 46 hours
  2. customThe solvent is evaporated
  3. customThe residue is triturated with 1 N hydrochloric acid
  4. filtrationfiltered
  5. customsucked dry
  6. customto give the product, mp 300° C. (dec)

Sources & evidence

ORD record
ord-912a0098905a4d19bb9b682e63afa1a0
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

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