HCID 12953041, compound → HCID 12953042, compound

HRID 904579Notes

Reaction equation

HRID 904579 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14]CC)=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][S:18][CH2:19][C:3]1=2>Cl>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][S:18][CH2:19][C:3]1=2

Participants

3

Reactant 1

HCID 12953041HCID 12953041, compound

Product 1

HCID 12953042HCID 12953042, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno[3,4-d]pyrimidine-7-carboxylate (0.25 g., 0.001 mol) in 2 N hydrochloric acid is refluxed for 2.5 hours. The reaction mixture is cooled in an ice-bath. The product is filtered off and recrystallized from dimethylformamide to give yellow crystals (0.14 g.), mp 311°-312° C.

Workup

  1. temperatureis refluxed for 2.5 hours
  2. temperatureThe reaction mixture is cooled in an ice-bath
  3. filtrationThe product is filtered off
  4. customrecrystallized from dimethylformamide
  5. customto give yellow crystals (0.14 g.), mp 311°-312° C.

Sources & evidence

ORD record
ord-c558a17aa6c7463fa1d34e14568a0541
Source dataset
uspto-grants-1980_10
Patent number
US04230707

Reaction notes

Loading…