Cyclophosphamide → AC regimen

Participants

Reaction Steps

To a dark orange solution of Doxorubicin (0.036 g), prepared from Doxorubicin hydrochloride as described in the previous experiment, in chloroform (100 ml) were added while stirring at 50° PLA (4.048 g), cis-Pta2Cl2 (0.495 g) and cyclophosphamide (0.381 g in 40 ml dichloromethane). The mixture was transferred to a 500 ml ball mill jar about one-third filled with pebbles, rotated overnight and worked up as reported in Example 1 to give two samples of average particle sizes of 250-425μ and 150-250μ.

Provenance & Evidence